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RNA Metabolism

RNAs are key players in most steps of gene expression.

Most cellular RNAs, regardless of their functions or size, work in close association with proteins in so-called RiboNucleoProtein particles or RNPs.

Our aim is to understand how RNPs are synthesized and work within the cells.

RNP biogenesis involves a large number of reactions including steps of RNA processing (mature sequences are generated from longer precursors), RNA modification (selected residues are modified), RNP assembly (RNAs are folded in 3-D and associate with proteins) and RNA transport (RNAs are specifically addressed from their sites of synthesis to their sites of function).

RNP biogenesis is essential for cell survival as shown by several autoimune and severe genetic diseases

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